Nelville Flynn is escorting a witness on a plane that is bound for Los Angeles. The problem is that an assassin is bent on killing the witness. The assassin releases a crate containing about 450 deadly snakes onto the same plane. Nelville finds out and he becomes bent on doing his job and getting the snakes back where they belong - on land. If the snakes won't cooperate with Nelville, he will just have to send the snakes on to snake heaven.

Vic and Donna Trenton struggle to repair their crumbling marriage. Their young son, Tad, befriends a hulking, lovable, 200-pound St. Bernard named Cujo. With Vic away on business, Donna and Tad take their rundown car to be fixed at the remote farm of their mechanic. As their Pinto dies, Cujo appears. But the once docile dog has undergone a hideous transformation, and becomes a slavering, demonic, implacable killer possessed by almost supernatural...