Stink Moody, friends Webster and Sophie, and Mrs. Birdwistle visit tourist attractions in Virginia as they try to give away 101 guinea pigs rescued from a laboratory, although Stink is very reluctant to relinquish his favorite, Astro.

Charlie, twelve, who has autism and obsessive compulsive disorder, must endure a cross-country trip with his siblings and a strange babysitter to visit their father, who will undergo brain surgery.