Searching to find the cure for a tatarigami's curse, Ashitaka travels the forests and becomes entangled in the bitter battles of the people that he meets.

Born to an esteemed family, Inu-oh is afflicted with an ancient curse that has left him on the margins of society. When he meets the blind musician Tomona, a young biwa priest haunted by his past, Inu-oh discovers a captivating ability to dance. The pair quickly become inseparable friends as crowds flock to their electric, larger-than-life concerts. But when those in power threaten to break up the band, Inu-oh and Tomona must dance and sing to uncover...