After a disturbing freshman year at New York University, Mimi is happy to get away to her father's remote Canadian cottage, only to discover a stranger living there who has never heard of her or her father and who is convinced that Mimi is responsible for leaving sinister tokens around the property.

A tragic local mystery from the past is blown wide open when a girl from the poor side of town infiltrates a group of reckless, wealthy boys and uncovers more than she could have imagined.

Thirteen-year-old Dan Cahill and his older sister, Amy, are the latest guardians of the Clues -- thirty-nine ingredients in a serum that transforms whomever takes it into the most powerful person on earth. They think they've done everything right, but a tiny mistake leads to catastrophe. The serum is missing and Dan and Amy have to get it back and stop who stole it ... before it's game over.