A successful plastic surgeon suspects that her politician husband has a shady past, and when he starts cheating on her, she and the Sisterhood decide to teach him a lesson.

In 1965, a dozen college girls launched their homemade raft on a trip down the Mississippi. Thirty-five years later, four of the "girls" make the same trip aboard a luxury steamboat to carry the ashes of a fifth to her final resting place. As the trip proceeds, each woman remembers the past and faces the choices she has made in her life.