Susan Murphy gets turned into a giant monster on her wedding day when a meteorite from outer space hits her. She is taken to a secret government compound where she meets a ragtag group of monsters also rounded up over the years. As a last resort, under the guidance of General W.R. Monger, on a desperate order from The President, the motley group of Monsters are called into action to combat the aliens and save the world from imminent destruction.

Susan Murphy gets turned into a giant monster on her wedding day when a meteorite from outer space hits her. She is taken to a secret government compound where she meets a ragtag group of monsters also rounded up over the years. As a last resort, under the guidance of General W.R. Monger, on a desperate order from The President, the motley group of Monsters are called into action to combat the aliens and save the world from imminent destruction.