The Reverend Jesse Custer is returning to the Alamo, a place of sacrifice, to end the quest that began in the burning remains of his church all those years ago - a quest to track down God and make Him answer for His actions.

"This is going to hurt! In a world where costumed heroes soar through the sky and masked vigilantes prowl the night, someone's got to make sure the "supes" don't get out of line. And someone will! Billy Butcher, Wee Hughie, Mother's Milk, The Frenchman, and The Female are The Boys: A CIA-backed team of very dangerous people, each one dedicated to the struggle against the most dangerous force on Earth - superpower! Some superheores have to be watched....

The Almighty has quit His Heaven, and the Reverend Jesse Custer - with the help of his girlfriend Tulip and his best friend, the Irish vampire Cassidy - aims to find out why. The Lord is hard to track, though, even for someone whose soul has been merged with a near-omnipotent supernatural entity called Genesis. To pick up the trail, Jesse needs to get inside his own head for a one-on-one talk with his guest - and for that, a fistful of peyote taken...

The Reverend Jesse Custer continues on his outrageous mission in the third Preacher collection. First Jesse and his girlfriend Tulip travel to France to search for their vampire pal Cassidy, who's in the midst of a war with a secret society called The Grail. Then Jesse and company return to New York, where Jesse learns the strange tale of Cassidy's transformation.