A follow-up to Mrs. Noodlekugel finds Nick and Maxine accompanying the eccentric lady to the eye doctor to help her four myopic mice who, after overindulging on cheesecake, go running into the streets, triggering a search that is aided by a helpful policemen and a rough-edged alley cat.

Nick and Maxine have a new babysitter--the eccentric Mrs. Noodlekugel who lives in the funny little house behind their drab high-rise apartment building along with her feline butler, Mr. Fuzzface, and three myopic mice.