Principal Krupp once again turns into the superhero Captain Underpants in order to save the world, and Jerome Horwitz Elementary School, from the evil talking toilets and the Turbo Toilet 2000.

When Professor Pippy P. Poopypants comes to Jerome Horwitz Elementary School to teach science, and he goes off the deep end because students make fun of his name, only Captain Underpants can save the school from the professor's perilous plot.

George and Harold, and their doubles, Yesterday George and Yesterday Harold, have a good thing going. Two of them go to school, while the other two hide in the tree house and play video games all day-then they switch! But when their malicious gym teacher, Mr Meaner, creates a method of mind control that turns their fellow students into attentive, obedient, perfect children, the future of all humanity will be in their hands!

Only Captain Underpants can stop the three evil space aliens who have invaded Jerome Horwitz Elementary School and turned everyone into lunchroom zombie nerds.

General Jackrabbit and his Robo-Rabbits from Jupiter attempt to take over the world on Ricky Ricotta's birthday.

Evil Uncle Unicorn attempts to dominate Earth by using a Ladybot to trick Mighty Robot.

A snotty situation ensues when Melvin Sneedley, an academically-gifted student, turns into the Bionic Booger Boy and must be stopped by George, Harold, and Captain Underpants.

"Excitement and imagination run wild as Naomi, Melvin, Poppy, Gilbert, Curly, and their siblings get back to making comics with originality and laughter. But wait--have they cleaned their rooms yet?! After their chores, the rambunctious group presents even more amazing mini-comics. By working together, the baby frogs discover that small things can have a huge impact"--

A small mouse named Ricky Ricotta and his best friend, a giant flying robot, save the world from Victor Von Vulture and his vicious voodoo vultures from Venus.