On a trip to a pond with a local nature group, twins Josh and Danny accidentally eat a muffin laced with Petty Potts' SWITCH spray and are transformed into very stinky beetles.

After accidentally drinking some of mad scientist Petty Pott's SWITCH potion while at school, twins Josh and Danny become grasshoppers and this time they may not change back without help.

Twins Josh and Danny continue following clues leading them to marbles filled with scientific code, despite the fact that mad scientist Petty Potts' REPTOSWITCH formula is having some very strange side-effects.

An intruder at mad scientist's Petty Potts' house interrupts her latest experiment, trying REPTOSWITCH on twins Josh and Danny, and when they return home they find a package that sends them on a mysterious quest.

Twins Danny and Josh reveal to neighbor Petty Potts that they have been on a quest to find marbles containing secret code and soon find themselves--as geckos--in her new secret laboratory within the very pink Princessland.

At summer camp, twins Josh and Danny and their new friend, Charlie, still have frog's legs from when "camp counselor" Petty Potts sprayed them with her new AMPHISWITCH, but a second attempt to restore them turns them into newts, instead.

When Petty Potts disappears, twins Danny and Josh search her secret laboratory and house, where they find an irresistible bottle of S.W.I.T.C.H. spray, and later they find themselves on a live television talk show.