For thirteen years, Vlad, aided by his aunt and best friend, has kept a secret that he is half-vampire, but when his missing teacher is replaced by a sinister substitute, he learns that there is more to being a vampire, and to his parents' deaths, than he could have guessed.

While half-vampire Vlad, his best friend Henry, and Henry's cousin Joss make their way through their freshman year at Bathory High, a hired vampire slayer seeks to destroy Vlad.