Zoe freaks out when she falls pregnant to her long-term boyfriend Tim. Tim embraces the idea of parenthood, while Zoe rushes away from it.

Ben is a 23-year-old slacker who meets up and coming career girl Alison at a bar. They end up having a one night stand. Eight weeks later, Ben is shocked when Alison meets him and reveals that she is pregnant. Despite having little in common, the two decide that they have to at least try to make some kind of relationship work for the baby's sake.

Angela is an ambitious, image-conscious businesswoman working for Mary, her over-demanding boss. When Angela becomes unexpectedly pregnant at the peak of her career, her life with Curtis, her divorce attorney husband, is turned upside-down. Now, this inconvenient pregnancy will lead to a nine-month roller coaster ride as Angela and Curtis try to cope. They have to deal with the interference of best friends, married couple Danny and Sylvia as emotions...

40-year-old virgin: 40-year-old Andy Stitzer has a cushy job stamping invoices at an electronics superstore, a nice apartment that includes a collection of action figures and comic books, good friends, a nice attitude. But at 40, Andy is still a virgin. His friends think he's a bit of an oddball, but they consider it their duty to help Andy out of his dire situation and decide to go to great lengths to help him. But nothing proves effective enough...