Welcome to the future where biological warfare has decimated life on Earth. Los Angeles is a windswept ghost town where Robert Neville tools his convertible through sunlit streets foraging for supplies. He fends off attacks by The Family-- sinister neopeople spawned by the plague. He also becomes a man with a mission after meeting Lisa, another infected survivor, and guardian of some healthy children representing our species' hope.

Male astronauts crash-land on an all-female planet Venus.