Sam, Lucy, and Antonio have a new substitute teacher, who happens to be the great-great-grandson of Orson Eerie, the evil scientist whose spirit possesses and infects their elementary school--and the friends are afraid he may be trying to bring Orson back to life.

"It lives. In a research hangar in Virginia, a Unit 51 team studies an ancient but long-dormant virus that can transform human physiology-and turn it into something else. . .It mutates. In the Amazon rainforest, a newly evolving life form known as Subject Z acquires the ability to think conceptually, build elaborate traps, create new carriers-and spawn a new race . . .It spreads. In Mexico and Turkey, the men and women of Unit 51 race to uncover a...

Kat is reluctant to visit her Uncle Vic Frankenstein because of all the rumors about him. People in the small town where he lives say he's a mad scientist like his great-grandfather, Victor Frankenstein, who created a monster that came alive and terrorized the town. But Kat is relieved to find that even though he lives in a dark, old castle-like mansion, Uncle Vic is a quiet, gentle man, a scientist interested in building robots with artificial intelligence....

When a lonely, eccentric old man decides to become a mad scientist and try "this Frankensteining business," two brothers, Jake and Derek, become unwitting participants in his experiments.

A mysterious private school has opened in town and Nick, Carter, and Angelo join forces with their rivals Angie, Tiffany, and Dana to uncover the mystery behind the school's inhumanly good football team.