While running a spy network from their elementary school, five unpopular misfits combine their talents and use cutting-edge gadgetry to fight evil around the world.

Former NERDS teammate Heathcliff Hodges introduces a virus to Arlington, Virginia, home of the NERDS headquarters, and it transforms people into superintelligent criminal masterminds. Flinch is determined to destroy the virus, and in order to do that, he must shrink himself and take a trip through Heathcliff's body.

When Ms. Information kidnaps the President's daughter, it is up to twelve-year-old Ruby, also known as Pufferfish, to use her super-nanobyte-enhanced allergies in leading the NERDS' investigation.

The campaign to save the earth from being turned off is going well, but Michael K. must enlist fellow fifth-graders Venus and TJ to help hide the SPHDZ from Agent Umber, especially when they become involved in a school play.

"To crack a secret code, Mac follows the clues to France and Japan where he must use his gaming skills and defeat his enemy, the KGB Man."--