Dead to Me stars Christina Applegate as Jen, a poised and put together woman with a dark sense of humor and an anger problem that she doesn't necessarily want to deal with. Jen has been struggling to keep it together in the months since her husband was killed in a hit-and-run accident. When she joins a grief support group she meets Judy (Linda Cardellini), a free spirit with a shocking secret.

Soon after giving birth to her first child, a woman gets into a car crash that puts her in a coma and wakes up seven years later.

After a major accident leaves two dead, two critically wounded, and the surviving victims' lives changed forever, the father of one of the victims files a suit against the police department. Detective Inspector John Tolin must come to terms with his own past, and with his partner in the investigation if he has any hope of untangling the carnage, and understanding what caused the accident that threw so many lives together.

When her fiancé Mike is left paralyzed following a tragic accident, Carrie Bell begins to question her familiar world, from her everyday life in Wisconsin to her relationships, as she sets out to rediscover her own identity.