Clifford the big red dog visits his veterinarian, Dr. Smart, who has given him a check-up every year since he was almost too small to be weighed.

Zoe must stay in Ambler with her grandmother and cousin while her mom films a movie. There she learns that several animals have been poisoned by antifreeze. Zoe and the rest of the Vet Volunteers try to raise awareness about antifreeze by doing public service announcements; and Zoe uses it as an excuse to get her mother's attention.