The year is 2033 and since a humongous meteor hit the earth, the world just hasn't been the same. A mega-villian, Kesslee (Malcolm McDowell), the leader of Water & Power, holds the world in his grasp since he controls all the water down to the last drop ... or so he thinks. Two colossal enemies stand in his way: the Rippers - an army of half-men/half-kangaroo people and Tank Girl - a chick with a tank and a ton of attitude, with a chip on her shoulder...

Scientist Bruce Banner has been living in the shadows, scouring the earth for an antidote to his curse of turning into the Hulk when he becomes angry and desperately missing Betty Ross, the only woman he has ever loved. He is pursued by warmongers who want to use his powers for their own purposes and a nightmarish beast of pure adrenaline and aggression called the Abomination whose powers match that of the Hulk. A fight of epic proportions ensues...