"A wild scream echoes across Metropolis, and when Batgirl and Supergirl investigate, they find that Silver Banshee is planning to broadcast a mind-control curse over the city"--Title verso page.

Welcome to the 31st century and the Legion Academy, where a new generation hones their powers with hopes of joining the Legion of Super-Heroes. Devastated by tragedy, Supergirl struggles to adjust to her new life on Earth. Taking her cousin Superman's advice, Supergirl leaves their space-time to attend the academy. There, she quickly makes new friends, as well as a new enemy with old ties: Brainiac 5. But a nefarious plot lurks in the shadows - the...

Supergirl's life gets complicated when a new enemy, Belinda Zee, shows up.

Supergirl wraps up all of the cosmic craziness that has developed since her arrival on Earth, including arch-frenemies, scheming faculty, an intergalactic orange kitty and a flying horse.

"When a seedpod from space crashes into Gotham City Batgirl, Supergirl, and Poison Ivy all rush to investigate--but while the two superheroes want to uproot the alien menace, Poison Ivy sees it as a powerful weapon"--Title verso page.

"Completing the H'el on Earth crossover event that had made its way through Superman, Superboy and finally Supergirl. A mysterious Kryptonian arrives on Earth and convinces Kara that he intends on returning them to Krypton, prior to its destruction, in an effort to save the planet. When presented with the opportunity to return home, the young and sometimes foolish Kara fails to see H'el's whole plan, a plan that will leave the Earth in ruins. Wonder...

"The Emerald Empress has had a vision. Sometime in the future, her greatest tragedy will come as a result of a battle with Supergirl...and she won't allow that to happen. Now she's manipulated Magog, Soloman Grundy, the sorceress Selena and the android indigo into joining her as the Fatal Five, and they're going to make sure that Supergirl's future stops dead in its tracks."--

"In this bold reimagining of the Girl of Steel, Lex Luthor's familiar synthetic creation "Matrix"--who mimics Superman's powers in a miniskirt--merges with human girl Linda Danvers to create a new Supergirl. These establishing issues develop their dynamic and set the stage for the compelling series while welcoming pivotal appearances by Superman, Gorilla Grodd and Ma and Pa Kent. Written by the legendary Peter David and illustrated by the artist behind...

"Lex Luthor is up to no good! He's trying to dig up deep-sea Kryptonite. Batgirl and Supergirl rush in to end his operation, but deadly green dust fills the cavern, draining the Girl of Steel's powers. What's worse, the tunnels are at risk of total collapse! Can the two Super Heroes stop Luthor's scheme before they're trapped beneath the waves?"--Back cover.

In the sixth and final season, Supergirl is thrust into the greatest challenge of her life; forced to confront her own mortality, and the prospect of losing all hope. As her friends rally to help her in this difficult fight, a new villain arrives in National City and tests her resolve.